Invitrogen™ CRB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA560462

Product Code. 15788291

Description

Immunogen sequence: RWDDGLRHLV MLSFGPDQLQ DLGQHVHVGG RLLAADSQPW GGPFRGCLQD LRLDGCHLPF FPLPLDNSSQ PSELGGRQSW NLT Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 75%.

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

Specifications

• Antigen: CRB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRB2
• Gene Alias: 5930402A21; BC043114; Crb2; crumbs 2; crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs2; crumbs-like protein 2; FSGS9; Protein crumbs homolog 2; RGD1309368; VMCKD
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 286204
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5IJ48
• Gene Symbols: CRB2
• Immunogen: Recombinant protein corresponding to Human CRB2. Recombinant protein control fragment (Product #RP-100819).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG