CRALBP Monoclonal Antibody (B2), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA1813

Product Code. 11549982

Description

MA1-813 detects CRALBP protein in bovine, human, mouse, non-human primate and rat samples. MA1-813 has successfully been used in Western blot, immunohistochemistry, immunoprecipitation, and immunofluorescence procedures. By Western blot, this antibody detects a 37 kDa protein representing human recombinant CRALBP. The MA1-813 immunogen is purified human recombinant CRALBP.

Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.

Specifications

• Antigen: CRALBP
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P10123, P12271, Q9Z275
• Gene Symbols: RLBP1
• Immunogen: Human recombinant CRALBP.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Mouse, Non-human Primate, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Clone: B2
• Conjugate: Unconjugated
• Gene: RLBP1
• Gene Alias: 3110056M11Rik; cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; CRALBP; retinaldehyde binding protein 1; retinaldehyde-binding protein 1; retinaldehyde-binding protein precursor; Rlbp1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 19771, 282038, 293049, 6017
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid