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Invitrogen™ Cortactin Monoclonal Antibody (4C6)

Product Code. 12847852
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Quantity:
100 μL
Unit Size:
100µL
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12847852 100 μL 100µL
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Product Code. 12847852 Supplier Invitrogen™ Supplier No. MA515831

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Description

Mouse Monoclonal Antibody

MA5-15831 targets CTTN in indirect ELISA, IHC and WB applications and shows reactivity with Human and mouse samples. The MA5-15831 immunogen is purified recombinant fragment of human CTTN expressed in E. Coli. . MA5-15831 detects CTTN which has a predicted molecular weight of approximately 80kDa.

Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cortactin
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 4C6
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene Cttn
Gene Accession No. Q14247, Q60598
Gene Alias 1110020L01Rik; amplaxin; cortactin; Cttn; Cttnb; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8; Unknown (protein for MGC:137923)
Gene Symbols Cttn
Host Species Mouse
Immunogen Purified recombinant fragment of human CTTN expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13043, 2017
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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