Invitrogen™ COPS8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA520539

Product Code. 12878712

Description

A suggested positive control is human liver tissue lysate. PA5-20539 can be used with blocking peptide PEP-0659.

COPS8 is a COP9 signalosome (CSN), which is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

Specifications

• Antigen: COPS8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cops8
• Gene Alias: 9430009J09Rik; AA408242; COP9; COP9 (constitutive photomorphogenic) homolog, subunit 8; COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana); COP9 constitutive photomorphogenic homolog subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; COP9 signalosome subunit 8; COPS8; Csn8; hCOP9; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108679, 10920, 363283
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q6P4Z9, Q8VBV7, Q99627
• Gene Symbols: Cops8
• Immunogen: A 15 amino acid peptide near the carboxy terminus of the human CSN8.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG