Invitrogen™ COPS7A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103079

Product Code. 16639534

Description

Antibody detects endogenous levels of total COPS7A.

The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I B-alpha and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.

Specifications

• Antigen: COPS7A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COPS7A
• Gene Alias: COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana); COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; COP9 complex subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A; COP9 signalosome complex subunit 7a; COP9 signalosome subunit 7A; COPS7A; CSN7; CSN7A; D6Ertd35e; dermal papilla-derived protein 10; DERP10; JAB1-containing signalosome subunit 7a; SGN7a; signalosome subunit 7a
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26894, 312710, 50813
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9CZ04, Q9UBW8
• Gene Symbols: COPS7A
• Immunogen: A synthesized peptide derived from human COPS7A(Accession Q9UBW8), corresponding to amino acid residues D234-N275.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG