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  6. Collagen Type I Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Collagen Type I Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Product Code. p-7206139 Shop All Proteintech Products
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150 μL
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Product Code. Quantity unitSize
16843464 20 μL 20µL
16833464 150 μL 150µL
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Product Code. 16843464 Supplier Proteintech Supplier No. 146951AP20UL

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Description

Rabbit Polyclonal Antibody

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.

Specifications

Antigen Collagen Type I
Applications Western Blot
Classification Polyclonal
Concentration 0.32 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene COL1A2
Gene Accession No. P02466, P08123, Q01149
Gene Alias Alpha 2 type I collagen, COL1A2, Collagen alpha 2(I) chain, Collagen Type I, collagen, type I, alpha 2, OI4
Gene Symbols Col1a2
Host Species Rabbit
Immunogen Collagen Type I Fusion Protein Ag6281
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100626716, 1278, 12843, 84352
Target Species Pig, Rat, Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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