Invitrogen™ COL21A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA556675

Product Code. 15754581

Description

Immunogen sequence: AKSSRFLTKI AVVLTDGKSQ DDVKDAAQAA RDSKITLFAI GVGSETEDAE LRAIANKPSS TYVFYVEDYI AISKIREVMK Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 45%.

COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.

Specifications

• Antigen: COL21A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COL21A1
• Gene Alias: alpha 1 chain-like collagen; COL1AL; COL21A1; COLA1L; Collagen alpha-1(XXI) chain; collagen type XXI alpha 1 chain; collagen, type XXI, alpha 1; FP633
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81578
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96P44
• Gene Symbols: COL21A1
• Immunogen: Recombinant protein corresponding to Human COL21A1. Recombinant protein control fragment (Product #RP-94805).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG