Invitrogen™ CMG2 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA519295

Product Code. 11347273

Description

This antibody is predicted to react with bovine and canine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.

Specifications

• Antigen: CMG2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANTXR2
• Gene Alias: 2310046B19Rik; anthrax toxin receptor 2; ANTXR cell adhesion molecule 2; ANTXR cell adhesion molecule 2; anthrax toxin receptor 2; ANTXR2; AW561899; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 118429
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P58335
• Gene Symbols: ANTXR2
• Immunogen: Synthetic peptide sequence (HEGLKLANEQIQK) corresponding to the internal amino acids of ANTXR2 (aa 121-134).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG