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Invitrogen™ Clusterin (CLU) Rat ELISA Kit
Sandwich ELISA Kit
Brand: Invitrogen™ ERCLUX10
Additional Details : Weight : 2.50000kg
Description
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.Specifications
P05371 | |
1.3 ng/mL | |
ELISA | |
Colorimetric Microplate Reader | |
Clu | |
<10% | |
HRP | |
RUO | |
2°C to 8°C | |
1 hr 20 min |
1.311 to 320 ng/mL | |
Biotin | |
Plasma, Serum, Supernatant | |
24854 | |
<12% | |
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers | |
10 x 96 Tests | |
Plasma, 1 μL|Serum, 1 μL|Supernatant, 100 μL | |
Apolipoprotein J | |
4 hr 45 min |