Invitrogen™ CLSTN1 Recombinant Rabbit Monoclonal Antibody (23GB3725), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA553640

Product Code. 30088927

Description

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.

Specifications

• Antigen: CLSTN1
• Classification: Recombinant Monoclonal
• Concentration: 0.9 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O94985, Q9EPL2
• Gene Symbols: CLSTN1
• Immunogen: A synthetic peptide of human CLSTN1 (920-981AA).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 23GB3725
• Conjugate: Unconjugated
• Gene: CLSTN1
• Gene Alias: 1810034E21Rik; alcadein alpha; alcadein-alpha; alc-alpha; alcalpha1; alcalpha2; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; calsyntenin-1; CDHR12; CLSTN1; clstn1 protein; CS1; CST-1; CSTN1; C-terminal fragment 1-alpha; CTF1-alpha; FLJ32258; fm67g03; Kiaa0911; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; Soluble Alc-alpha; wu:fk52g02; wu:fm67g03; XB31alpha; zgc:153744; zgc:56528
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22883, 65945
• Content And Storage: -20°C
• Form: Liquid