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Clofarabine
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Product Code. 18777756
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25 mg
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18777756 5 mg 5mg
18738746 25 mg 25mg
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Product Code. 18777756 Supplier Tocris Bioscience Supplier No. 2600/5

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Description

Deoxycytidine kinase (dCK) substrate

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
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Specifications

Chemical Name or Material 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
CAS 123318-82-1
Assay Percent Range >99%
Quantity 5 mg
Molecular Formula C10H11ClFN5O3
Formula Weight Observed MW: 303.68
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