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Invitrogen™ CLIP1 Polyclonal Antibody

Product Code. 12858722
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Quantity:
100 μg
Unit Size:
100µg
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12858722 100 μg 100µg
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Product Code. 12858722 Supplier Invitrogen™ Supplier No. PA520545

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20545 can be used with blocking peptide PEP-0665.

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLIP1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CLIP1
Gene Accession No. P30622, Q922J3, Q9JK25
Gene Alias 1110007I12Rik; 4631429H07Rik; AV017631; C81039; CAP-Gly domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CLIP; Clip 170; Clip1; CLIP170; CLIP-170; Clip50; Cyln1; cytoplasmic linker protein 1; Cytoplasmic linker protein 170; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein 50; cytoplasmic linker protein CLIP-170; Kiaa4046; MGC131604; mKIAA4046; Reed-Steinberg cell-espressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-espressed intermediate filament-associated protein); restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); Rsn
Gene Symbols CLIP1
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the carboxy terminus of human CLIP170.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56430, 6249, 65201
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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