Invitrogen™ Claudin 4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA534437

Product Code. 15395361

Description

A suggested positive control is human colon tissue lysate. PA5-34437 can be used with blocking peptide PEP-1479.

Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl^- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Specifications

• Antigen: Claudin 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cldn4
• Gene Alias: Cep-r; claudin 4; CLAUDIN4; claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; Cpetr; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1364
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O14493
• Gene Symbols: Cldn4
• Immunogen: A 17 amino acid synthetic peptide near the carboxy terminus of human CLAUDIN4.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG