Invitrogen™ CKMT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA528591

Product Code. 13462707

Description

Recommended positive controls: 293T, A431, HeLa, HepG2. Predicted reactivity: Mouse (91%), Rat (91%), Dog (94%), Pig (94%), Rabbit (92%), Chicken (84%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: CKMT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ckmt2
• Gene Alias: 2300008A19Rik; basic-type mitochondrial creatine kinase; CKMT2; Creatine kinase S-type, mitochondrial; creatine kinase, mitochondrial 2; creatine kinase, mitochondrial 2 (sarcomeric); creatine kinase, mitochondrial 2, sarcomeric; EC 2.7.3.2; mib-CK; sarcomeric mitochondrial creatine kinase; ScCKmit; SMTCK; S-MtCK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1160
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P17540
• Gene Symbols: Ckmt2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human CKMT2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG