Invitrogen™ CK1 epsilon Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595934

Product Code. 16588771

Description

Immunogen sequence: EFSTYLNFCR SLRFDDKPDY SYLRQLFRNL FHRQGFSYDY VFDWNMLKFG AARNPEDVDR ERREHEREER MGQLRGSATR ALPPGPPTGA TANRLRSAAE PVASTPASRI QPAGNTSPRA ISRVDRERKV SMRLHRGAPA NVSSSDLTGR QEVSRIPASQ TSVPFDHLGK; Positive Samples: HeLa, 293T; Cellular Location: Cytoplasm, Nucleus.

CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis. CSNK1E phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.

Specifications

• Antigen: CK1 epsilon
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CSNK1E
• Gene Alias: AI426939; AI551861; AW457082; casein kinase 1; casein kinase 1 epsilon; casein kinase 1, epsilon; casein kinase I isoform epsilon; CK1e; CK1epsilon; CKI, epsilon; CKIe; CKIepsilon; CKI-epsilon; Csnk1e; HCKIE; KC1 epsilon; KC1epsilon; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1; tau
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1454, 27373, 58822
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P49674, Q9JMK2
• Gene Symbols: CSNK1E
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 247-416 of human CSNK1E (NP_6894071).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG