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Invitrogen™ Chromogranin A Recombinant Mouse Monoclonal Antibody (PD01-39)

Description
Positive control: Human pancreas tissue, human thyroid tissue, human atypical carcinoid tissue, human medullary thyroid carcinoma tissue, human appendix tissue. Predicted band size: 51 kDa Subcellular Location: Cytoplasmic vesicle, Secreted.
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
Specifications
Specifications
| Antigen | Chromogranin A |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Recombinant Monoclonal |
| Clone | PD01-39 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 |
| Gene | Chga |
| Gene Accession No. | P10645 |
| Gene Alias | AL-11; AL26; Beta-granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHGA; ChrA; chromofungin; chromogranin A; chromogranin A (parathyroid secretory protein 1); chromogranin A precursor; chromogranin-A; CTNNB; DKFZp686D02253; EA-92; ER-37; ES-43; FLJ25606; FLJ37923; GE-25; GR-44; GV-19; LF-19; LOW QUALITY PROTEIN: chromogranin-A; MGC105435; Pancreastatin; Parastatin; parathyroid secretory protein 1; p-Glu serpinin precursor; pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP-I; SS-18; Vasostatin I; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14 |
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