Chromogranin A Mouse, Clone: LK2H10 + PHE5, Novus Biologicals™

Mouse Monoclonal Antibody

Marca:  Novus Biologicals NBP2-34239-0.02MG

Código de producto. 18179332

Descripción

Chromogranin A Monoclonal specifically detects Chromogranin A in Human, Mouse, Rat, Porcine, Monkey samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Especificaciones

• Antigen: Chromogranin A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: betagranin (N-terminal fragment of chromogranin A), CGA, chromogranin A (parathyroid secretory protein 1), chromogranin-A, parathyroid secretory protein 1, Pituitary secretory protein I, SP-I
• Host Species: Mouse
• Molecular Weight of Antigen: 72 kDa
• Quantity: 0.02 mg
• Research Discipline: Apoptosis, Cancer, Neuronal Cell Markers
• Gene ID (Entrez): 1113
• Target Species: Human, Mouse, Rat, Primate
• Form: Purified

• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
• Clone: LK2H10 + PHE5
• Dilution: Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
• Gene Accession No.: P10645
• Gene Symbols: CHGA
• Immunogen: Human pheochromocytoma (LK2H10 & PHE5)
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
• Content And Storage: Store at 4C.
• Isotype: IgG1