Invitrogen™ CHRM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA586501

Product Code. 16343385

Description

Purity is > 95% by SDS-PAGE.

Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.

Specifications

• Antigen: CHRM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHRM2
• Gene Alias: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; AChR-M2; Acm2; cardiac muscarinic acetylcholine receptor; cholinergic receptor; cholinergic receptor muscarinic 2; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; Chrm2; Chrm-2; FLJ43243; HM2; M2; M2 muscarinic acetylcholine receptor; m2AChR; M2-mAChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; muscarinic acetylcholine receptor m2; muscarinic M2 receptor; muscarinic receptor m2; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1129, 243764, 81645
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P08172, P10980, Q9ERZ4
• Gene Symbols: CHRM2
• Immunogen: Synthetic peptide, corresponding to amino acids 191-240 of Human mAChR M2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG