Chorionic Gonadotropin beta Chain (hCG beta) Antibody (SPM529), Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-34369-0.02MG

Product Code. 18196884

Description

Chorionic Gonadotropin beta Chain (hCG beta) Monoclonal specifically detects Chorionic Gonadotropin beta Chain (hCG beta) in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Chorionic Gonadotropin beta Chain (HCG beta)
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: CGB3choriogonadotropin subunit beta, CGB5, CGB7, CGB8, CG-beta, Chorionic gonadotrophin chain beta, chorionic gonadotropin beta 3 subunit, chorionic gonadotropin beta chain, chorionic gonadotropin beta subunit, chorionic gonadotropin, beta polypeptide, hCGB
• Host Species: Mouse
• Molecular Weight of Antigen: 22 kDa
• Quantity: 0.02 mg
• Research Discipline: Cancer
• Gene ID (Entrez): 1082
• Target Species: Human
• Form: Purified

• Applications: Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
• Clone: SPM529
• Dilution: Western Blot 0.5-1ug/ml, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml
• Gene Accession No.: P01233
• Gene Symbols: CGB
• Immunogen: Recombinant hCG beta protein
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: This MAb reacts with a protein of 22kDa, identified as beta sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the ? and ? subunits. The ? subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.
• Content And Storage: Store at 4C.
• Isotype: IgG1