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Tocris Bioscience™ Cholesterol
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Product Code. 18706015
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Quantity:
100 mg
Unit Size:
100mg
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Product Code. 18706015

Brand: Tocris Bioscience™ 7945/100

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This item is not returnable. View return policy

Description

Component of lipid nanoparticles (LNPs); modulator of lipid bilayer fluidity

Cholesterol is a major sterol in all mammalian organisms; it is an essential component that makes up about 20-25% of the structural lipids of cell membranes. Cholesterol determines the permeability and fluidity characteristics of the cell membranes. Cholesterol is an endogenous ligand for estrogen-related receptor α (ERRα). It is also a precursor in several biosynthetic pathways, including steroid hormones and the active form of vitamin D. Cholesterol is a component of lipid nanoparticles (LNPs), and is important in modulating membrane stability, with the effect being context dependent. When combined with lipids that have low gel-liquid crystalline phase transition temperature (Tm), Cholesterol reduces membrane fluidity and increases bilayer thickness; when combined with high Tm lipids, it increases membrane fluidity and narrows the bilayer thickness.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (3β)-Cholest-5-en-3-ol
CAS 57-88-5
Quantity 100 mg
Target Lipid Nanoparticles
Molecular Formula C27H46O
Purity 0.95
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