Invitrogen™ CHMP4A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA564372

Product Code. 15772132

Description

Immunogen sequence: THLPAGPAPK VDEDEEALKQ LAEWVS Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 42%.

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

Specifications

• Antigen: CHMP4A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHMP4A
• Gene Alias: C14orf123; CDA04; Charged multivesicular body protein 4a; CHMP4; CHMP4A; CHMP4B; chromatin modifying protein 4A; Chromatin-modifying protein 4a; hSnf-1; HSPC134; hVps32-1; SHAX2; SNF7; SNF7 homolog associated with Alix-2; Snf7 homologue associated with Alix 2; SNF7-1; Vacuolar protein sorting-associated protein 32-1; VPS32-1; VPS32A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29082
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BY43
• Gene Symbols: CHMP4A
• Immunogen: Recombinant protein corresponding to Human CHMP4A. Recombinant protein control fragment (Product #RP-104057).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG