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  6. Invitrogen™ CHK2 Recombinant Rabbit Monoclonal Antibody (K01_3L23)

Invitrogen™ CHK2 Recombinant Rabbit Monoclonal Antibody (K01_3L23)

Product Code. 30828529
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30828529 100 μL
30828879 50 μL
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Product Code. 30828529 Supplier Invitrogen™ Supplier No. MA564384

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: TSTMPNSSQS SHSSSGTLSS LETVSTQELY SIPEDQEPED QEPEEPTPAP WARLWALQDG FANLECVNDN YWFGRDKSCE YCFDEPLLKR TDKYRTYSKK HFRIFREVGP KNSYIAYIED HSGNG Highest antigen sequence identity to the following orthologs: Mouse - 87%, Pig - 89%, Cynomolgus monkey - 74%.

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHK2
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone K01_3L23
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene Chek2
Gene Accession No. O96017
Gene Alias CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Gene Symbols Chek2
Host Species Rabbit
Immunogen Recombinant protein of human Chk2 (aa 43-167).
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11200
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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