missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Invitrogen™ Chk1 Recombinant Rabbit Monoclonal Antibody (K01_1P51)

Invitrogen™ Chk1 Recombinant Rabbit Monoclonal Antibody (K01_1P51)
GREENER_CHOICE

Product Code. 30828645
Change view
Click to view available options
Quantity:
50 μL
100 μL
Unit Size:
100µL
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
30828645 100 μL 100µL
30827460 50 μL -
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 30828645 Supplier Invitrogen™ Supplier No. MA563589

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Rabbit Recombinant Monoclonal Antibody

Chk1 Recombinant Monoclonal Antibody for Western Blot

CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Chk1
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1P51
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene Chek1
Gene Accession No. O14757, O35280, Q91ZN7
Gene Alias C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Gene Symbols Chek1
Host Species Rabbit
Immunogen A synthetic peptide of human Chk1.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1111, 12649, 140583
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.