Invitrogen™ Chitotriosidase Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582395

Product Code. 16389354

Description

Immunogen sequence: FDDVESFKTK VSYLKQKGLG GAMVWALDLD DFAGFSCNQG RYPLIQTLRQ ELSLPYLPSG TPELEVPKPG QPSEPEHGPS PGQDTFCQGK ADGLYPNPRE RSSFYSCAAG RLFQQSCPTG LVFSNSCKCC TWN Highest antigen sequence indentity to the following orthologs: Rat - 73%, Mouse - 70%.

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

Specifications

• Antigen: Chitotriosidase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHIT1
• Gene Alias: 2300002L19Rik; CHI3; CHIT; Chit1; CHITD; chitinase 1; chitinase 1 (chitotriosidase); chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1118
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13231
• Gene Symbols: CHIT1
• Immunogen: Recombinant protein corresponding to Human CHIT1. Recombinant protein control fragment (Product #RP-90229).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG