CDKN2A, Chicken, Biotin, Polyclonal Antibody, Abnova™

Chicken polyclonal antibody against synthetic peptide of CDKN2A

Brand:  Abnova PAB27958.50ug

Product Code. 16047847

Description

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq

Sequence: IDAAEGPSDIPD

Specifications

• Antigen: CDKN2A
• Classification: Polyclonal
• Conjugate: Biotin
• Formulation: In Phosphate-Buffered Saline with 0.02% Sodium Azide.
• Gene Alias: ARF/CDK4I/CDKN2/CMM2/INK4/INK4a/MLM/MTS1/TP16/p14/p14ARF/p16/p16INK4/p16INK4a/p19
• Host Species: Chicken
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 1029
• Content And Storage: Store at 4°C. For long term storage aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
• Isotype: IgY

• Applications: Immuno-MRM (Multiple Reaction Monitoring)
• Concentration: 1 mg/mL
• Description: Chicken polyclonal antibody against synthetic peptide of CDKN2A
• Gene: CDKN2A
• Gene Symbols: CDKN2A
• Immunogen: A Synthetic peptide corresponding to amino acids of CDKN2A
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

For Research Use Only