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CHFR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16899713 Shop All Proteintech Products
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150 μL
Unit Size:
150µL
20µL
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16899713 20 μL 20µL
16889713 150 μL 150µL
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Product Code. 16899713 Supplier Proteintech Supplier No. 121691AP20UL

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Description

Rabbit Polyclonal Antibody

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the ′Lys-48′-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of ′Lys-63′-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at ′Lys-63′ are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Specifications

Antigen CHFR
Applications Western Blot, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CHFR
Gene Accession No. Q810L3, Q96EP1
Gene Alias CHFR, RING finger protein 196, RNF116, RNF196
Gene Symbols Chfr
Host Species Rabbit
Immunogen CHFR Fusion Protein Ag2811
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 231600, 288734, 55743
Target Species Rat, Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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