CHCHD6 Mouse anti-Human, Clone: 2A11E9, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16808625	Proteintech 66597-1-IG-20UL	20 μL
16898615	Proteintech 66597-1-IG-150UL	150 μL

Description

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Specifications

• Antigen: CHCHD6
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CHCHD6
• Gene Symbols: CHCHD6
• Isotype: IgG2a
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 2A11E9
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: Q9BRQ6
• Gene ID (Entrez): 84303
• Immunogen: CHCHD6 Fusion Protein Ag14700
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CHCHD6