missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 17100252

STEMCELL Technologies Chaetocin

Product Code. 17100252
Encompass_Preferred
Click to view available options
Quantity:
500 μg
Unit Size:
500µg
This item is not returnable. View return policy

Product Code. 17100252

Brand: STEMCELL Technologies 73592

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Epigenetic modifier; Inhibits histone methyltransferase SU(VAR)3-9

  • Chaetocin is a fungal mycotoxin, originally produced by Chaetomium species, that inhibits the lysine-specific histone methyltransferases (HMTs) SU(VAR)3-9 (IC50 = 0.8 μM)
  • HMTs are responsible for methylation of histones, thereby affecting heterochromatinization
  • Chaetocin is also known to inhibit G9a and DIM5 (IC50 = 2.5 μM and 3 μM respectively; Cherblanc et al.; Greiner et al.) Chaetocin also acts as a competitive substrate and inhibitor of the central oxidative stress remediation enzyme thioredoxin reductase-1 (TrxR1; Km = 4.6 μM) more potently than glutathione reductase or thioredoxin (Tibodeau et al.)
  • Induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells (Isham et al.; Spannhoff et al.)
  • Attenuates the growth of glioma xenografts accompanied by an increase in reactive oxygen species (ROS) production (Dixit et al.)

Specifications

CAS 28097-03-2
Synonym Chaetocin A
Quantity 500 μg
Molecular Formula C30H28N6O6S4
Purity ≥95%
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.