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  5. Tocris Bioscience™ CGS 21680 hydrochloride

Tocris Bioscience™ CGS 21680 hydrochloride
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Product Code. 30001186
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Product Code. 30001186 Supplier Tocris Bioscience™ Supplier No. 1063/10

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253.30 GBP valid until 2026-03-31
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Description

A2A agonist

CGS 21680 hydrochloride is a potent A2A adenosine receptor agonist (Ki = 27 nM, EC50 = 1.48-180 nM). CGS 21680 reduces venous resistance, increases heart rate and cardiac output in vivo. In an animal model of Huntington's disease, CGS21680 slows motor deterioration, prevents reduction in brain weight and reduces the size of mutant huntingtin aggregates and intranuclear inclusions. CGS21680 increases proliferation of neural progenitor cells, promotes survival of motoneurons and activates TrkB receptors. Also has anti-inflammatory effects in animal models of lung injury and reduces neurotoxicity induced by Kainate (Cat. No. 7065).
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 124431-80-7
Molecular Formula C23H30ClN7O6

Specifications

Quantity 10 mg
Formula Weight 535.99
Purity >98%
Molecular Weight (g/mol) 535.986
Chemical Name or Material CGS 21680 hydrochloride
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