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Invitrogen™ cGKI Polyclonal Antibody

Product Code. 16579001
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16579001 100 μL 100µL
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Product Code. 16579001 Supplier Invitrogen™ Supplier No. PA596164

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGTLRDLQYA LQEKIEELRQ RDALIDELEL ELDQKDELIQ KLQNELDKYR SVIRPATQQA QKQSASTLQG EPRTKRQAIS AEPTAFDIQD LSHVTLPFYP KSPQSKDLIK EAILDNDFMK NLELSQIQEI VDCMYPVEYG KDSCIIKEGD VGSLVYVMED GKVEVTKEGV KLCTMGPGKV FGELAILYNC TRTATVKTLV NVKLWAIDRQ CFQTIMMRTG LIKHTEYMEF LKSVPTFQSL PEEILSKLAD VLEETHYENG EYIIRQGARG DTFFIISKGT VNVTREDSPS EDPVFLRTLG; Positive Samples: HepG2; Cellular Location: Cytoplasm.

PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen cGKI
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PRKG1
Gene Accession No. P0C605, Q13976
Gene Alias AAT8; AW125416; cGK; cGK 1; CGK 1 alpha; cGK 1 beta; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP dependent protein kinase type 1; cGMP kinase type I alpha; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase 1, alpha isozyme; cGMP-dependent protein kinase 1, beta isozyme; cGMP-dependent protein kinase I; Gm19690; OTTHUMP00000019618; PKG; Pkgi; Prkg1; PRKG1B; PRKGR1A; PRKGR1B; protein kinase cGMP-dependent 1; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type I; RP11-346D6.1; Unknown (protein for MGC:134126); unnamed protein product
Gene Symbols PRKG1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRKG1 (NP_0062491).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19091, 5592
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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