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Invitrogen™ CENPO Polyclonal Antibody

Product Code. 12849002
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Quantity:
100 μg
Unit Size:
100µg
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12849002 100 μg 100µg
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Product Code. 12849002 Supplier Invitrogen™ Supplier No. PA520826

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse kidney tissue lysate. PA5-20826 can be used with blocking peptide PEP-0940.

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CENPO
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CENPO
Gene Accession No. Q8K015, Q9BU64
Gene Alias 2810429O05Rik; 8430427C03Rik; CENPO; CENP-O; Centromere protein O; centromeric protein O; D12Ertd482e; ICEN36; ICEN-36; Interphase centromere complex protein 36; MCM21R
Gene Symbols CENPO
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the center of human CENPO.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 52504, 684439, 79172
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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