Invitrogen™ CENPB Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA565869

Product Code. 15918604

Description

Immunogen sequence: TFREKSRIIQE VEENPDLRKG EIARRFNIPP STLSTILKNK RAILASERKY GVASTCRKTN KLSPYDKLEG LLIAWFQQIR AAGLPVKGII L Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Specifications

• Antigen: CENPB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CENPB
• Gene Alias: CENPB; CENP-B; CENP-B protein; centromere autoantigen B; centromere protein B; centromere protein B, 80kDa; major centromere autoantigen B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1059
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Western Blot, Immunocytochemistry
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P07199
• Gene Symbols: CENPB
• Immunogen: Recombinant Human CENPB. Recombinant protein control fragment (Product #RP-106539).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG