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Thermo Scientific™ CellSensor™ c-Fos-bla ME-180 Cell Line

Product Code. 10042863
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Product Code. 10042863 Supplier Thermo Scientific™ Supplier No. K1650

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Description

The CellSensor™ c-fos-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the c-fos response element stably integrated into ME-180 cells.

The CellSensor™ c-fos-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the c-fos response element stably integrated into ME-180 cells. To construct this cell line, the c-fos-bla construct was transduced into ME-180 cells by lentivirus. Flow cytometry was used to isolate cells responsive to epidermal growth factor (EGF). This cell line is validated for DMSO tolerance, cell number, stimulation time, substrate loading time, as well as Z' and EC50 concentrations for EGF. The CellSensor™ c-fos-bla ME-180 cell line is responsive to EGF, HGF, IL-6, OSM, TNFα, IL-1-alpha; and PMA/Thaps, and can be used to probe the JNK/P38/MAPK and JAK/STAT signaling pathways. This cell line can be adapted for high-throughput screening of agonist or antagonist compound libraries. Candidate drugs can also be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.

TRUSTED_SUSTAINABILITY

Specifications

Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Description CellSensor™ c-Fos-bla ME-180 Cell Line, 1Vial, ∽ 2,000,000 cells/vial at 2,000,000 cells/mL Quantity of Cells, c-Fos-bla ME-180 Cell Line, Fluorescent Detection Method, CellSensor™ Druggable Target, Adherent Growth Properties, Liquid Nitrogen Storage
Detection Method Fluorescent
For Use With (Application) Pharma and biopharma, drug discovery and development, target and lead identification and validation, pathway biology, cellular pathway analysis assays, cellsensor™ cellular pathway assays
Includes beta-lactamase reporter gene under control of the c-Fos response element stably integrated into ME-180 cells
Product Line CellSensor
Quantity 1 Vial
Sample Type c-Fos-bla ME-180
Target Entry STAT1, STAT3, JAK1, EGFR, ERK1/2, p38, MAPK pathway, RAF, JAK2, c-MET, JNK, JAK/STAT (IFN gamma, IL-6/OSM) pathway, RON, MEK
Type Cell Line
System Type CellSensor™
Druggable Target Signaling Pathway
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For Research Use Only. Not for use in diagnostic procedures.

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