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CDT1 Rabbit anti-Human, Polyclonal, Proteintech

Product Code. p-7205718 Shop All Proteintech Products
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Quantity:
20 μL
150 μL
Unit Size:
150µL
20µL
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Product Code. Quantity unitSize
16833004 20 μL 20µL
16823004 150 μL 150µL
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Product Code. 16833004 Supplier Proteintech Supplier No. 143821AP20UL

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Description

Rabbit Polyclonal Antibody

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of ′Lys-4′ of histone H3 (H3K4me) complex and acetylation of ′Lys-16′ of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on ′Thr-3′, less activity toward H3 dimethylated on ′Arg-8′ or ′Lys-9′, and has higher activity toward H3 acetylated on ′Lys-9′. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

Specifications

Antigen CDT1
Applications Western Blot, Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CDT1
Gene Accession No. Q9H211
Gene Alias CDT1, DNA replication factor Cdt1, Double parked homolog, DUP, RIS2
Gene Symbols CDT1
Host Species Rabbit
Immunogen CDT1 Fusion Protein Ag5810
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81620
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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