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Invitrogen™ CDK9 Polyclonal Antibody
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Product Code. 16545991
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Quantity:
100 μL
Unit Size:
100µL
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16545991 100 μL 100µL
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Product Code. 16545991 Supplier Invitrogen™ Supplier No. PA587517

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ANVLITRDGV LKLADFGLAR AFSLAKNSQP NRYTNRVVTL WYRPPELLLG ERDYGPPIDL WGAGCIMAEM WTRSPIMQGN TEQHQLALIS QLCGSITPEV WPNVDNYELY EKLELVKGQK RKVKDRLKAY VRDPYALDLI DKLLVLDPAQ RIDSDDALNH DFFWSDPMPS DLKGMLSTHL TSMFEYLAPP RRKGSQITQQ STNQSRNPAT TNQTEFERVF; Positive Samples: LO2, HeLa, A-549, SKOV3, Mouse brain, Rat testis; Cellular Location: Cytoplasm, Nucleus, PML body.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK9
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CDK9
Gene Accession No. P50750, Q641Z4, Q99J95
Gene Alias C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Gene Symbols CDK9
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 153-372 of human CDK9 (NP_0012521).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1025, 107951, 362110
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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