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Invitrogen™ CDK9 Monoclonal Antibody (1B5D10)

Product Code. 12837872
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Quantity:
100 μL
Unit Size:
100µL
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12837872 100 μL 100µL
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Product Code. 12837872 Supplier Invitrogen™ Supplier No. MA515850

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Beskrivning

Mouse Monoclonal Antibody

MA5-15850 targets CDK9 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15850 immunogen is purified recombinant fragment of human CDK9 expressed in E. Coli. . MA5-15850 detects CDK9 which has a predicted molecular weight of approximately 43kDa.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CDK9
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1B5D10
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene CDK9
Gene Accession No. P50750
Gene Alias C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Gene Symbols CDK9
Host Species Mouse
Immunogen Purified recombinant fragment of human CDK9 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1025
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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