Invitrogen™ CDK7 Recombinant Rabbit Monoclonal Antibody (BL-80-5D4)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
17735579	Invitrogen™ MA544207	100 μL
17745579	Invitrogen™ MA544208	20 μL

Description

Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.

Specifications

• Antigen: CDK7
• Concentration: 40 μg/mL
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
• Gene Accession No.: P50613
• Gene ID (Entrez): 1022
• Immunogen: Synthetic peptide representing a region between residues 300 and the C-terminus (residue 346) of human Cyclin-Dependent Kinase 7.
• Product Type: Antibody

• Clone: BL-80-5D4
• Content And Storage: 4°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: CDK7
• Gene Alias: 39 KDa protein kinase; 39 protein kinase; AI323415; AI528512; C230069N13; CAK; CAK1; CDK; CDK7; CDK-activating kinase; CDK-activating kinase 1; Cdkn7; cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); cyclin dependent kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; HCAK; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; Mpk-7; OTTHUMP00000222032; OTTHUMP00000222033; p39 Mo15; p39MO15; Protein-tyrosine kinase MPK-7; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; STK1; TFIIH basal transcription factor complex kinase subunit
• Gene Symbols: CDK7
• Primary or Secondary: Primary
• Purification Method: purified