CDK5 Monoclonal Antibody (DC34), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen AHZ0492

Product Code. 10373973

Description

Suggested positive controls include HT29, MAD109, PC12 cells and brain tissue.

The protein encoded by this gene is a neuron-specific activator of cyclin-dependent kinase 5; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer′s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer′s disease.

Specifications

• Antigen: CDK5
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Gene: CDK5
• Gene Alias: CDK5 activator 1, TPKII regulatory subunit, cyclin-dependent kinase 5 activator 1, cyclin-dependent kinase 5 regulatory subunit 1, neuronal CDK5 activator, regulatory partner for CDK5 kinase, tau protein kinase II 23kDa subunit
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 1020, 12568, 140908
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Clone: DC34
• Conjugate: Unconjugated
• Gene Accession No.: Q00535, P49615, Q03114
• Gene Symbols: CDK5
• Immunogen: Recombit cdk5 protein.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1 κ