Invitrogen™ CDK4/CDK6 Recombinant Rabbit Monoclonal Antibody (HL2323)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA556640

Product Code. 30276423

Description

CDK4/CDK6 Recombinant Monoclonal Antibody for Western Blot

CDK4 (Cyclin-Dependent Kinase 4) and CDK6 (Cyclin-Dependent Kinase 6) are crucial regulators of the cell cycle, specifically involved in the transition from the G1 phase to the S phase. These kinases form complexes with D-type cyclins (Cyclin D1, D2, and D3), which are necessary for their activation. Once activated, CDK4 and CDK6 phosphorylate the retinoblastoma protein (RB1), leading to the release of E2F transcription factors that drive the expression of genes required for DNA synthesis and cell cycle progression. Dysregulation of CDK4 and CDK6 activity is a common feature in various cancers, as it can lead to uncontrolled cell proliferation. Consequently, CDK4 and CDK6 have become important targets in cancer therapy, with inhibitors such as palbociclib, ribociclib, and abemaciclib being developed and approved for the treatment of certain types of cancer, particularly hormone receptor-positive breast cancer. These inhibitors work by blocking the kinase activity of CDK4 and CDK6, thereby halting cell cycle progression and reducing tumor growth.

Specifications

• Antigen: CDK4/CDK6
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P11802, P30285, P35426, Q00534, Q64261
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1019, 1021, 114483, 12567, 12571, 94201
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Clone: HL2323
• Conjugate: Unconjugated
• Gene: CDK4
• Gene Symbols: CDK4, CDK6
• Immunogen: Recombinant fragment of human CDK4 + CDK6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG