Invitrogen™ CDK11A/CDK11B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5101273

Product Code. 16627754

Description

Antibody detects endogenous levels of total CDK11.

CDK11 is a member of the cyclin-dependent kinase 11 family which is known to be essential for eukaryotic cell cycle control and it is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. CDK11 is a negative regulator of normal cell cycle progression and Its expression is regulated during murine embryogenesis, and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle. CDK11 gene may harbor 1 or more tumor suppressor genes that affected by chromosome 1p36 modifications in neuroblastoma. CDK11 could be cleaved by caspases and was demonstrated to play roles in cell apoptosis.

Specifications

• Antigen: CDK11A/CDK11B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDK11B
• Gene Alias: AA989746; Cdc11b; Cdc2l1; CDC2L2; CDC2L3; CDC-related protein kinase p58; CDK11; CDK11A; Cdk11b; CDK11-p110; CDK11-p46; CDK11-p58; cell division cycle 2 homolog-like 1; cell division cycle 2 homolog-like 2; cell division cycle 2-like 1; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2; cell division cycle 2-like 2 (PITSLRE proteins); cell division cycle 2-like protein kinase 1; Cell division cycle 2-like protein kinase 2; cell division protein kinase 11; Cell division protein kinase 11A; cell division protein kinase 11B; CLK-1; cyclin dependent kinase 11A; cyclin dependent kinase 11B; cyclin-dependent kinase 11; Cyclin-dependent kinase 11A; cyclin-dependent kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; p58; p58 CLK-1; p58CDC2L1; p58CLK-1; p58GTA; PITSLRE; PITSLRE B; PITSLRE protein kinase beta; PITSLRE proteins; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLRE serine/threonine-protein kinase CDC2L2; PITSLREA; PITSLREB; PK58
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 728642, 984
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P21127, Q9UQ88
• Gene Symbols: CDK11A, CDK11B
• Immunogen: A synthesized peptide derived from human CDK11A(Accession Q9UQ88), corresponding to amino acid residues D212-D262.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG