CD98, Rabbit anti-Human, Clone: HBJ127, Novus Biologicals™

Rabbit Monoclonal Antibody

Product Code	Brand	Quantity
18267929	Novus Biologicals NBP2-81109-0.025MG	0.025 mg
18249218	Novus Biologicals NBP2-81109-0.2MG	0.2 mg

Description

CD98 Monoclonal specifically detects CD98 in Human samples. It is validated for ELISA, Immunocytochemistry/Immunofluorescence, Block/Neutralize.

Specifications

• Antigen: CD98
• Concentration: 1 mg/mL
• Applications: ELISA, Immunofluorescence, Blocking Assay
• Conjugate: Unconjugated
• Host Species: Rabbit
• Research Discipline: Biologically Active Proteins, Cell Biology, Cellular Markers, Immunology, Lipid and Metabolism, Plasma Membrane Markers, Signal Transduction
• Formulation: PBS
• Gene ID (Entrez): 6520
• Immunogen: HBJ127 was obtained from hybridomas generated by the fusion of mouse myeloma cells and spleen cells from mice which had been immunized with T24 hyman bladder cancer cells.
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Clone: HBJ127
• Dilution: ELISA, Immunocytochemistry/Immunofluorescence, Block/Neutralize
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Alias: 4F2, 4F2hc, 4T2HC, antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC, CD98, CD98 antigen, CD98 heavy chain, CD98HC, heavy chain, Lymphocyte activation antigen 4F2 large subunit, MDU1antigen defined by monoclonal 4F2, heavy chain, monoclonal 44D7, NACAE4F2 cell-surface antigen heavy chain, solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen
• Gene Symbols: SLC3A2
• Isotype: IgG κ
• Purification Method: Protein A purified
• Test Specificity: HBJ127 binds to the CD98 heavy chain at an epitope consisting of residues AFS (aa 442-444) (Itoh et al, 2007). The antibody has not been shown to cross-react with other species. CD98 is expressed at high levels on monocytes and at very low level on peripheral blood T and B lymphocytes, splenocytes, NK cells and granulocytes. CD98 is a disulfide-linked and glycosylated type II integral membrane protein. This protein has roles in normal and neoplastic cell growth and is required for the function of light chain amino acid transporters. It is also involved in sodium-independent transport of large neitral amino acids and in guiding and targeting LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, CD98 acts as an arginine/glutamine exchanger.