CD86 (B7-2) Rat anti-Mouse, Clone: GL1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0862-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15267097

Quantity Price
1 £ 133.91 / 500µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Gene Alias B72, B7.2, B70, Ly-58
Isotype IgG2a
Species Reactivity Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Clone GL1
Format Purified
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Primary or Secondary Primary
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Antigen CD86 (B7-2)
Quantity 500μg
Host Species Rat

The GL1 monoclonal antibody reacts with mouse CD86, an ∽80kDa surface receptor also known as B7-2. CD86 & CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). This interaction plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation, supports its major contribution during the primary phase of an immune response.