CD86 (B7-2) Mouse anti-Rat, FITC, Clone: 24F, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-0860-81

50UG ANTI-RAT CD86 (B7-2) FITC

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15268139

Quantity Price
1 £ 82.0 / 50µg
Estimated Shipment date
from Supplier 09-12-2016
Add to basket


Description and Specification

Specification

Antigen CD86 (B7-2)
Applications Flow Cytometry
Clone 24F
Concentration 0.5mg/mL
Conjugate FITC
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias B72
Host Species Mouse
Isotype IgG1
Quantity 50μg
Regulatory Status RUO
Species Reactivity Rat
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The 24F monoclonal antibody reacts with rat CD86, an ∽90kDa surface receptor, also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed by germinal center B cells and at low levels on macrophages, dendritic cells and non-lymphoid cells in the thymus. Its expression is upregulated on B cells through a variety of surface stimuli including LPS. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.