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CD86 (B7-2) Mouse anti-Human, Clone: IT2.2, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-0869-85

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15218527

  • £213.39 / 500µg


Estimated Shipment
30-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The IT2.2 monoclonal antibody reacts with human CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.
Description & Specifications

Specifications

CD86 (B7-2)
IT2.2
Unlabeled
aqueous buffer, no sodium azide
Murine
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
Purified
B72, B70
IgG2b
RUO
Primary
Human