CD86 (B7-2) Mouse anti-Human, Biotin, Clone: IT2.2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0869-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15279639

Quantity Price
1 £ 133.91 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Conjugate Biotin
Clone IT2.2
Gene Alias B72, B70
Isotype IgG2b
Primary or Secondary Primary
Antigen CD86 (B7-2)
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze.
Regulatory Status RUO
Format Conjugated
Quantity 100μg

The IT2.2 monoclonal antibody reacts with human CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.