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CD85k (ILT3) Monoclonal Antibody (ZM4.1), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£105.00 - £242.00
Specifications
Antigen | CD85k (ILT3) |
---|---|
Clone | ZM4.1 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15528116
|
Affymetrix eBioscience
17-5139-42 |
100 Tests |
£242.00
100 tests |
Estimated Shipment: 14-05-2024 Log in to see stock. |
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15518116
|
Affymetrix eBioscience
17-5139-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The monoclonal antibody ZM4.1 recognizes ILT3, also known as CD85k. ILT3 is a member of the large family of ILT molecules (Immunologulin-like Transcripts, Leucocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs). ILT3 is a 60kDa transmembrane protein with two Ig domains and ITIMs. Expression is found on monocytes, macrophages, and dendritic cells. High levels of ILT3 expression is also found on plasmacytoid dendritic cells (pDCs). ILT3 expression by DCs has been shown to be required to induce Regulatory Tcells (tregs). Addition of ZM4.1, like ZM3.8, blocks the suppressive function of the Tregs in in vitro culture systems with allogenic DC's. Applications Reported: This ZM4.1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This ZM4.1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].Specifications
CD85k (ILT3) | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
Q8NHJ6 | |
LILRB4 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
LILRB4 |
ZM4.1 | |
Flow Cytometry | |
APC | |
Mouse | |
Human | |
11006 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.