CD85g (ILT7) Mouse anti-Human, PE, Clone: eBio17G10.2 (17G10.2), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5179-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15507006

Quantity Price
1 £ 176.7 / 100 tests
EU Stock 1
Add to basket


Description and Specification

Specification

Clone eBio17G10.2 (17G10.2)
Antigen CD85g (ILT7)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias ILT-7, LILRA4
Concentration 5μL (0.125μg)/test
Monoclonal or Polyclonal Monoclonal
Conjugate PE
Primary or Secondary Primary
Regulatory Status RUO
Isotype IgG1
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100 tests
Applications Flow Cytometry
Host Species Mouse
Format Conjugated

The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 is part of the leukocyte immunoglobulin-like receptor (LIR) gene family and associates with Fc epsilon R1 gamma to form a functional complex which transduces ITAM-mediated signals that negatively modulates TLR-induced type I IFN production by human plasmacytoid dendritic cells. ILT7 is expressed exclusively on plasmacytoid dendritic cells and is absent in monocyte derived DCs. Treatment with IL-3 or CpG causes a decrease in expression.

Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 yields virtually complete co-staining. Cross linking of ILT7 with eBio17G10.2 antibody causes reduced transcription of IFN alpha1, IFN alpha2, IFN alpha4 and IFN beta.