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CD80 Hamster anti-Mouse, FITC, Clone: 16-10A1, BD
Hamster Monoclonal Antibody
£146.89 - £236.34
Specifications
| Antigen | CD80 |
|---|---|
| Clone | 16-10A1 |
| Concentration | 0.5mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15891499
|
BD Biosciences
561954 |
0.1 mg |
 £154.00 £146.89 / Each Save £7.11 4% Off |
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|
15867378
|
BD Biosciences
553768 |
0.5 mg |
£247.00 £236.34 / Each Save £10.66 4% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
The 16-10A1 antibody reacts with CD80 (B7-1). This member of the Ig superfamily, along with CD86 (B7-2), participates in T-cell co-stimulation via interactions with CD28 and CD152 (CTLA-4). CD80 has been reported to be constitutively expressed on dendritic cells, monocytes, and peritoneal macrophages; and it is inducible on B cells by various means, including activation by LPS, IL-4, and the cross-linking of surface Ig. Expression of CD80 has been reported to be greatly enhanced on splenic B cells following activation by LPS, with peak expression occurring between 48 and 72 hours. It has been reported that the activation of purified B cells with LPS can induce CD80 expression in as few as 18 hours. The 16-10A1 antibody has been reported to block binding of CTLA-4 Ig to CD80 and to block T-cell activation by Con A-elicited peritoneal exudate cells and CD80-transfected cell lines. However, 16-10A1 antibody alone is not able to block T-cell activation by antigen-presenting cells. CD86 (B7-2) is an alternate ligand for CD28 and CD152 (CTLA-4). Preliminary reports indicate that the 16-10A1 mAb may block the binding of rat anti-CD80 mAb clone 1G10 (Mfr. No. 553368). In addition, it has been reported that the 16-10A1 antibody may cross-react with an activation antigen expressed on IFN-γ-activated alveolar macrophages of the dog.
Host Species: Hamster
Clone: 16-10A1
Isotype: IgG2 κ
Species Reactivity: Mouse
Immunogen: Mouse CD80 (B7) Transfected Cell Line
Flow Cytometry
Specifications
| CD80 | |
| 0.5mg/mL | |
| Monoclonal | |
| Hamster | |
| Mouse | |
| Mouse CD80 (B7) Transfected Cell Line | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| 16-10A1 | |
| Flow Cytometry | |
| FITC | |
| RUO | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| IgG2 κ | |
| Affinity Purified | |
| Cd80; B7; B7-1; Cd28l; Ly-53; MIC17; TSA1 |
For Research Use Only.
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