CD8 Mouse anti-Human, Clone: OKT8 (OKT-8), Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0086-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288367

Quantity Price
1 £ 201.16 / 500µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Species Reactivity Human
Primary or Secondary Primary
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.
Format Purified
Gene Alias CD8 alpha, leu-2a
Antigen CD8
Conjugate Unlabeled
Isotype IgG2a
Clone OKT8 (OKT-8)
Quantity 500μg
Applications Flow Cytometry
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO

The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.