CD8 Mouse anti-Human, Alexa Fluor 700, Clone: OKT-8, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 56-0086-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15332110

Quantity Price
1 £ 140.02 / 100µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Format Conjugated
Isotype IgG2a
Quantity 100μg
Concentration 0.2mg/mL; 5μL (0.06μg)/test
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias CD8 alpha, leu-2a
Clone OKT8 (OKT-8)
Antigen CD8
Regulatory Status RUO
Primary or Secondary Primary
Conjugate Alexa Fluor 700
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.